Sentence examples for are refractory to multiple from inspiring English sources

Importantly, REM tumors are refractory to multiple rounds of chemotherapy and patients fail to respond to this line of treatment.

As our NDI1-HCT 116 p53−/− cells are refractory to multiple effects of metformin in vitro, we reasoned that if metformin acted directly on mitochondrial complex I within the tumor cells to reduce tumorigenesis then NDI1-HCT 116 p53−/− xenograft tumors would not be inhibited in their growth.

Patient 1 was refractory to multiple medications but achieved long-term quiescence with GLM; the change in the interval dosing schedule for GLM likely reflects the aggressive nature of her disease.

We present the treatment of a patient with a particularly large plantar keloid that was refractory to multiple excisions, adjunctive intralesional steroids, and radiation therapy, who was successfully treated with excision, intralesional steroids, and tissue-engineered allograft placement.

In 1999 an entangled right whale catalogued by the New England Aquarium as #2030 (http://rwcatalog.neaq.org) proved to be refractory to multiple disentanglement attempts.

If blood pressure is refractory to multiple agents, clinicians should consider an evaluation for secondary forms of hypertension.

Ru and Liebman (2003) reported two patients with chronic lymphocytic leukaemia (CLL) and a CD8 T-LGL leukaemia who were refractory to multiple treatments for PRCA.

While these anecdotal clinical cases suggest that the G1202R mutant may be refractory to multiple therapies, our work provides a systematic analysis of the relative potency of all drugs against this mutation.

Complex drug therapy is effective in most of the patients with severe and resistant hypertension, but there are certain individuals who may be refractory to multiple-drug regimens or have adverse effects that make adherence to the regimen difficult.

However, our findings suggest that these signaling pathways, while important for eye formation, are not sufficient for the promotion of ectopic eye development as most cells within the Dpp and Hh expression domains of multiple tissues are refractory to the forced expression of individual or combinations of RD genes.

Mice deficient for the amino acid transporter ASCT2 are refractory to the induction of experimental allergic encephalomyelitis, an animal model of multiple sclerosis [ 24].