The phrase "are refined in a" is correct and usable in written English.
It can be used when describing a process or state of improvement or enhancement in a particular context.
Example: "The techniques used in this study are refined in a way that maximizes efficiency and accuracy."
Alternatives: "are improved in a" or "are enhanced in a".
The HADDOCK docking protocol consisted in three steps: randomization of orientations and rigid body minimization, semi-flexible simulated annealing in torsion angle space and flexible solvent refinement where the structures obtained after the semi-flexible simulated annealing are refined in an explicit solvent layer.
During postnatal development, the dendrites of spinal motor neurons are refined in an activity-dependent manner that can be influenced by blocking activation of N-methyl-d-aspartate (NMDA) receptors.
Their focus was refined in a series of workshops on what was known, unknown, and unknowable (KUU) about the subject.
For this reason, Tennessee is a proving ground for the principal change in the proposed bankruptcy law, now being refined in a Senate-House committee.
"This is because the crude oil available in Raqqa [Isis captured most of the Syrian oilfields] is refined in a rough-and-ready way and then exported to Iraqi regions under Isis control.
There is still a grit to the brand but it's been refined, in a natural kind of a way, because now I'm 31, not 21, so there are things I didn't like before that I like now; things I liked before and now want a better version of.
The annotation of the genome was refined in a multi-step approach, including modern bioinformatic pipelines, transcriptome and proteome data.
Their scheme of meta-categories was refined in a way that allowed for a distinction between the conventional and the renewable energy sector in particular.
The model was refined in a backward stepwise manner, excluding at each step the least significant of any variables not significant at p < 0.05.
