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The residues missing in the shorter NT fragments are reasonably conserved between IP3R subtypes and they lack cysteine residues (Supplementary Figure S1B).
Nonetheless, currently available data supports the application of mammalian molecular screening data to assessing chemical hazards for a range of nonmammalian species, provided that relevant toxicity pathways are reasonably conserved and understood.
We identified 1,701 genes that are single copy in both Theileria species and are reasonably conserved for substitution rate analysis at the nucleotide level (i.e., d S <= 1).
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VP35 consists of several helices, and is reasonably conserved in the Marburg virus from the same Filoviridae family (42% identity, 58% similarity).
For example, although this region is reasonably conserved among A. thaliana, A. lyrata, C. rubella, and T. halophila, it is not well conserved with other rosid PAB6 orthologs (data not shown).
Furthermore, we found that both the neutrophil and the lymphocyte gene expression signatures that we had described were reasonably conserved in an independent group of kidney transplant patients from a multicentre international study.
The Aus0085 prophage are distinct to the prophage regions present in Aus0004 and TX16, although as demonstrated in Figure 1C, many of the CDS that make up phiEnfa004 also appear in the other two genomes, which suggests this prophage is reasonably conserved.
Furthermore, the regions at the junction of the translocation are reasonably well conserved among different accessions, which suggests that the translocation was a single evolutionary event.
The residues involved in the salt bridges formed upon ATP binding are reasonably well conserved in all GroEL sequences.
Other central components of the MAP kinase module (Ste11, Pbs2) and phosphorelay module (Ypd1, Ssk1, Ssk2) are reasonably well conserved across the diverse species analysed.
Since the GTFs are reasonably well conserved, it might be assumed, even though molecular functional analyses are still lacking, that they govern transcription initiation and elongation as in other eukaryotes [ 26, 42].
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