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The side chains in this salt bridge network are rather disordered, indicating they are probably not forming a rigid network supporting the extended conformation (Figure 1C).
Also residues in the peptide are rather disordered; these observations bring into question the suggested triggering role of the peptide in the formation of a 2∶2 complex [14].
Rather, an α-helix of the metavinculin insert (coined H1') and its amino-terminal extended coil replace the H1 α-helix and its amino-terminal extended coil that are present in Vt, which are no longer part of the MVt domain but are rather disordered in the metavinculin structure (Figure 1; Supplementary Figures S1, S2, S3).
As indicated by the average B-factors, the C-terminal domains of the both A and B subunits are rather disordered and it was not possible to model side chains accurately.
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Both non-structural proteins of the influenza A viruses were predicted to be rather disordered.
For instance, the Vpr protein which is present in HIV but is not expressed in SIV [ 36] and structure of which was determined by NMR is predicted to be rather disordered (39% by PONDR® VLXT and 64% by PONDR® VL3, Table 3).
It is rather difficult to imagine how such disordered systems are propagated in a stable manner for millions of years, and it is also not entirely clear how they emerged in the first place.
The effect of nonnative hydrophobic interactions on the capture rate kcap was rather small for all systems and the disordered system possessed a slower capture rate (Figure 6A).
Using the information in Table 2, we can tell that gp120 can be considered as quite ordered by prediction, whereas the gp41 should be categorized as rather disordered.
Second, multimeric substrates adopt natural, rather disordered, geometries that are well accounted for in molecular dynamics (MD) simulations.
Its value (25%) indicates a rather disordered structure that is visualized in terms of a detailed model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com