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The phrase "are radically different" is correct and usable in written English.
It can be used to emphasize a significant difference between two or more subjects or ideas.
Example: "The two approaches to solving the problem are radically different, leading to varied outcomes."
Alternatives: "are vastly different" or "differ significantly".
Dictionary
are radically different
adverb
In a radical manner; fundamentally; very.
Exact(59)
Sometimes the documents themselves are radically different; sometimes the differences consist of a few missing commas here and there.
Furthermore, the structural profiles of promoters differ greatly between eukaryotes and prokaryotes as the transcription complexes are radically different.
Their expectations are radically different.
Two decades on, things are radically different.
What if the styles are radically different?
The formats, of course, are radically different.
All seven films are radically different.
But their approaches are radically different.
Skinner and Drew are radically different urban bards.
The women are radically different in their responses to the outer world and to Wroe.
"They are radically different from what Anzhi built in these past years," Villas-Boas said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com