Sentence examples for are problematic to estimate from inspiring English sources

As argued by Kislyuk et al. [ 17] such extrapolation estimates are likely to be spurious because they depend on the estimation of the occurence of extremely rare genes and genomes, respectively, which are problematic to estimate precisely because they are rare.

However, as snares are difficult to detect and often dispersed widely across large, inaccessible areas it is problematic to reliably estimate their prevalence and no standard survey methods exist.

It is therefore problematic to estimate the desired sample size.

However, it is problematic to use conventional mutation rate estimates to calculate when the j and t haplotypes diverged from a single common ancestor because a significant proportion of a KIR haplotype is coding sequence and much of the non-coding DNA may be functional.

Even in the occasional cases which are problematic, the estimated curves provide a helpful starting point for manual adjustment.

Therefore, the maximum likelihood estimate of q j would be zero for those samples, which are problematic point estimates.

Although the sample size was large, violations of normality can be problematic in estimating rates of change using maximum likelihood estimation [ 51].

He admitted that issuing fines would be problematic, but estimated that 90 percent of smokers would comply with the law.

Because it was presumed that, as usually, the measured medical costs would follow a skewed distribution, a normality assumption would be problematic when estimating confidence intervals.

Such "recycling" of RIMS-samples is not problematic, inasmuch as the samples are used to estimate two independent quantities.

Calculating risk from seafood exposure to persistent organic pollutants continues to be problematic as estimates of exposure from diet require extensive monitoring of fish species and limited assessments of bioavailability from sediments where the contaminants tend to reside.