The phrase "are problematic in terms of" is correct and usable in written English.
It can be used to discuss issues or challenges related to a specific aspect or context of a subject.
Example: "The proposed changes to the policy are problematic in terms of their potential impact on employee morale."
Alternatives: "pose challenges regarding" or "are concerning with respect to".
In general, ketone/aldehyde condensations are best suited for conjugation reactions in vitro or at the cell surface because the reaction requires an acidic pH and high concentrations of the labeling reagent, which are problematic in terms of cell toxicity [224].
For example, if the constructs used to represent the cause and effect are problematic in terms of their definitions and measurements, this will have consequences for all other aspects of validity and will seriously affect the validity of the causal claims.
In addition, the authors used the allogeneic chondrocytes, which are problematic in terms of their antigenicity.
CpG sites in loci that are problematic in terms of alignment need to be eliminated prior to analyses, as coverage estimates will be confounded with alignment errors.
Specifically, the databases which result from the collection of morbidity data from polyclinics and hospitals (the sources of most morbidity data) are problematic in terms of their diagnostic accuracy [ 55].
A common solution has been to employ various convenience sampling methods which, although clearly viable with respect to accessing these populations, are problematic in terms of generating conclusions or estimates that are generalizable to the population from which the sample was obtained.
"They feel that it's problematic, in terms of the way we have submitted it," he said.
Cannabis (hemp) and Humulus (hop) have long been problematic in terms of their placement with other members of the suborder.
On the other hand, NMs can also be problematic in terms of eliciting a toxicological effect by their small size.
"That sense of fear and awe and being problematic in terms of being involved in death is very much the same feeling people get when they see hawks.
"As well as unfairly stigmatising women, media coverage of binge drinking is problematic in terms of communication information about a serious health issue to the public.
