However, although glucocorticoids are often quite effective, their adverse effects are problematic and include weight gain, osteoporosis, immunosuppression, altered glycemic control, glaucoma, fractures, muscle wasting, and hypertension (Table 1), which are counter-balanced by using the lowest possible dose for the shortest period of time.
In the results sections, selective reporting was problematic and included reporting of only pre-selected events (for example, fractures and ophthalmologic complications [ 80]), events known to be associated with GC therapy [ 17], events occurring in more than two patients [ 29], or events leading to withdrawal).
If this is right, the conclusion is very radical indeed: any sort of love that is directed at anything other than the just and good and fine will be problematic, and this will include love of family, friends, and fellow-citizens, except insofar as they are just, good and fine.
These models are found to be problematic and are modified by including multiple optima that reflect the specific ecological conditions under consideration.
In addition, prescriptions with directions that include 'as needed' may be problematic and lead to variable interpretations of the days' supply to be recorded (eg, 4 puffs/day, with a maximum of 8 puffs/day as needed).
Previous research has demonstrated that S. lycopersicoides is tolerant to abiotic stresses such as cold injury and nutrient deficiency, and is simultaneously resistant to diverse pathogens that are problematic on tomato, including viruses (tomato mosaic virus and cucumber mosaic virus), oomycetes (Phytophthora parasitica), and fungi (Cladosporium fulvum and Botrytis cinerea) [ 30, 31, 58].
Although current drug dosing strategies during AKI are problematic, including an inability to quantify glomerular filtration rate accurately, clinicians diligently attempt to adjust renally eliminated drugs.
They suggest that this approach is inconsistent with our motivation "that cyclical downturns may be problematic to include" and hence suggest that "it is odd to hone in on the variation that the HP filter characterizes as business cycle variation" (p. 74).
To clarify, a chapter in the evidence and case studies produced with the report did not directly compare the risks, but said history presented examples of innovation trajectories that later proved to be problematic - including thalidomide and asbestos - and that innovations including hydraulic fracking arguably offered a contemporary prospective example.
Since the demands and centrality of forgiveness vary between the different faiths, it might be problematic to include the term as part of our notion of political reconciliation, especially in cases of inter-religious conflict.
While any number of independent results can be combined using our method, it is problematic to include mapping results from the same reference population even when phenotyping was entirely independent.
