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The phrase "are primarily manifested in" is correct and usable in written English.
It can be used to describe how certain characteristics or effects are mainly expressed or displayed in a particular context or situation.
Example: "The symptoms of the disease are primarily manifested in the respiratory system, leading to difficulty in breathing."
Alternatives: "are mainly expressed in" or "are chiefly exhibited in".
Exact(2)
Influences of climate changes on vegetation are primarily manifested in the alteration of the basic biogeochemical functions first of all, the exchange rates of water vapor and carbon dioxide between plant ecosystems and the atmosphere.
After all, potential PAINS pitfalls of academic scientists are easier to spot than those of their colleagues in the pharmaceutical industry because academic accidents are primarily manifested in publications, whereas failures in pharma environments are typically not publicized.
Similar(58)
This difference was primarily manifested in lower pharmacy costs for patients not escalating dose; for example, annual infliximab costs were 60% higher for patients escalating dose ($15,998 vs. $10,000; p < 0.001).
Expression of SOD1G93A in mice causes neurological dysfunction, which is primarily manifested by hind limb paralysis and motor neuron defect (20, 29, 30).
The stress-induced damage is primarily manifested as cavitation and dynamic microstructural evolution.
This disparity was primarily manifested within non-fatal disorders.
The effect of STZ-induced diabetes was primarily manifested on the rate of aortic flow.
Differences were primarily manifested during the latter 50% of stance, and were persistent when controlling for velocity.
A clear differentiation of tension, compression and shear is in nature primarily manifested in the properties of materials adapted to the efforts, whereas they in engineering are distributed on different components.
Nonlinearity of strain in rocks is manifested primarily in the stress dependency of tangent or secant elasticity modulus and Poisson's ratio and is caused by closure, initiation, propagation and linkup of pre-existing and new microcracks, frictional sliding along cracks, growth of dislocations, etc.
Whereas α-synuclein is abundantly expressed in various parts of the brain, intracellular aggregation and neuronal damage is primarily, and first manifested in dopaminergic neurons.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com