PDN is primarily managed with medication but analgesic failure is common and people remain in pain and distress.
Patients with diarrhea were primarily managed with loperamide and/or diphenoxylate/atropine (69%), and less frequently with temporary bosutinib dose interruptions (15%) and reductions (6%).
Diarrhea was primarily managed with antidiarrheal medication in both bosutinib (46%) and imatinib (31%) arms; among these patients, the median (range) duration of concomitant medication for diarrhea was 2 (1−741) and 4 (1−281) days, respectively.
Additionally, ALT and AST AEs infrequently led to treatment discontinuation (n = 11 and n = 0; Table 3) and were primarily managed with dose interruptions (57% and 41% of patients with an event, respectively), and less frequently with dose reductions (31% and 13%) or concomitant medication (30% and 22%).
Chemotherapy was primarily managed with the PEB regimen consisting of cisplatin (DDP, 20 mg/m, days 1 5 or 80 100 mg/m, day 1), etoposide (VP-16, 60 100 mg/m, days 1 5) or teniposide (VM-26, 60 100 mg/m, days 1 5), and bleomycin (BLM, 10 mg/m, day 1).
They are primarily managed for wood production, but have some capacity to support native fauna.
(55%) and Eucalyptus nitens H. Deane & Maiden (24%), which are primarily managed for short-rotation pulpwood production.
In Singapore, public health initiatives are primarily managed by government statutory boards, the Singapore Health Promotion Board (HPB).
Patients with existing cardiovascular diseases, patients at high risk based on familial hypercholesterolaemia only and patients who are primarily managed in secondary care (e.g. by cardiologists or internists or in rehabilitation programmes) will be excluded from the study.
The variation in costs also reflects disease-specific differences in management; e.g. IHD and ESRD include hospitalization and expensive procedures, whereas hypertension is primarily managed as an outpatient with inexpensive medications.
