Stricker et al. [ 35] suggested that phosphorylation as well as dimerisation are prerequisites for binding ACE2 to its target promoter.
In the presence of molecular oxygen, the HIF-α subunit is hydroxylated by specific oxygen-, iron- and 2-oxoglutarate-dependent prolyl hydroxylases (PHDs), which is prerequisite for binding of the von Hippel-Lindau (VHL) protein, the recognition component of an ubiquitin ligase complex that targets HIF-α for proteasomal degradation.
Furthermore the monomer ligand concentrations are prerequisite for the determination of the number of binding sites on the protein and of the equilibrium dissociation constants Kd's through which important thermodynamic information can be obtained.
We showed that the Asn112 and Asp116 residues are prerequisites for the binding of Na+ ions and accepting protons from the retinal Schiff base in the O and M photointermediates, respectively.
We found the collagen-immanent secondary triple-helical structure and the modified amino acid Hyp to be prerequisite for gelatinase binding.
Since some of the αIIb and β3 residues critical for skelemin binding (αIIbF and β3H) are also involved in the formation of the αIIbβ3 clasp, it appears that unclasping of the tails is prerequisite for skelemin binding.
It was shown that both phosphorylation of TEBPβ and binding of telomerase are prerequisites for this process, but probably not sufficient to unfold G-quadruplex structure in timely manner to allow replication to proceed.
Both are prerequisites for notification.
As polymerase-ε binding is prerequisite for both pgRNA packaging and protein priming, RNP formation represents an attractive early target for antiviral development.
In order to target EGFR for cancer therapy, however, an EGFR-specific mAb or binding peptide sequence is prerequisite for targeting highly expressed EGFR cells.
The latter is prerequisite for Banjo.
