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The phrase "are predominately responsible" is correct and usable in written English.
It can be used when discussing the main causes or factors contributing to a particular outcome or situation.
Example: "The researchers found that environmental factors are predominately responsible for the decline in bee populations."
Alternatives: "are mainly accountable" or "are primarily responsible".
Dictionary
are predominately responsible
adverb
In a predominate manner; predominantly
Exact(1)
Unlike WT PBsome, the increase of PE emission intensity during the bleaching was not seen, suggesting that B-PE molecules which are located at the peripheral side of WT PBsome rods are predominately responsible for the energetic decoupling of PBsome, whereas b-PE is probably not involved.
Similar(58)
Objective: To determine the direct action of RU486 on endometrial cell proliferation and to differentiate whether the antioxidant or the antiprogesterone property of RU486 is predominately responsible for its effect on cell growth.
Some Tory MP and peers, Lord Lawson being the most prominent, have cast doubt on scientific theories on climate change which argue that human activity is predominately responsible for recent rises in global temperatures.
But some Tory MPs and peers, Lord Lawson being the most prominent, have cast doubt on scientific theories on climate change which argue human activity is predominately responsible for recent rises in global temperatures.
However, whether ADAMTS4 or ADAMTS5 is predominately responsible for the cleavage of aggrecan in arthritis in humans remains controversial.
The cytochrome P450 enzyme CYP2E1 is predominately responsible for metabolizing CCl4, generating reactive oxygen species that induce centrilobular hepatic necrosis (Wong et al., 1998).
Furthermore, the low concentration and 'smear' migration pattern of DNA from 6-month-old Tg ovaries indicated that necrosis was predominately responsible for the ovarian degeneration at this stage.
We hypothesise that relatively subtle alterations in toxin expression levels within the major venom toxin families are likely to be predominately responsible for prey specificity, although we cannot rule out a contributory role for novel putative venom toxins, such as lysosomal acid lipase.
An extensive analysis of resected catheters from patients provides supporting observations that the growth of cells in our 3D culture system closely mimics what we observe on resected catheters and supports our proposal that astrocytes and microglia migrating from the brain parenchyma may be predominately responsible for cell obstruction of catheter holes.
These are predominately rational conceptual disciplines.
The Chamorro are predominately Roman Catholic.
More suggestions(15)
are fundamentally responsible
are dominantly responsible
are principally responsible
are basically responsible
are mainly responsible
are inherently responsible
are chiefly responsible
are substantially responsible
are notably responsible
are essentially responsible
are overwhelmingly responsible
are heavily responsible
are mostly responsible
are primarily responsible
are largely responsible
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com