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For both L1 and IAP the three mechanisms are in place within spermatogonia, however the derepression of IAP in MiliKO spermatogonia indicates that DNA methylation and or the piRNA pathway are predominantly required for the maintenance of IAP silencing therein.
Finally, it seems that Gsc and the Vent1/2 genes are predominantly required in their normal side of expression, while after removal of all three they seem to be dispensable for embryonic pattern formation.
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SMF-1 may thus be the counterpart of NRAMP1 in the worm, being predominantly required for Fe uptake.
This observation is consistent with a previous study of Gram-positive Lactococcus spp. lipoprotein processing that found that lipid modification is predominantly required to retain proteins at the membrane cell-wall interface [36].
It was surprising to find that hsf-1 was predominantly required during development and again, to a lesser extent, during adulthood.
These phenotypes are equivalently rescued by low level, neuron-specific expression of Drosophila or human wild-type spastin transgenes, indicating that Spastin is predominantly required in neurons, and functions similarly in both organisms (Sherwood et al., 2004; Du et al., 2010).
These regions are predominantly hydrophobic, as required for optimal positioning within the hydrophobic environment of the lipid membrane.
Sitagliptin, vildagliptin, saxagliptin, and alogliptin are predominantly renally excreted and require dose reductions to be made when prescribed to patients with moderate or severe renal impairment and with end-stage renal disease.
In a network whose communication channels are predominantly self-excitable, it is required that the NED (γN−γN−1)/N is maximal and (γN−1)/N minimal.
Although mice are predominantly endothermic, they appear to require external sources of heat to generate a fever.
In a network whose communication channels are predominantly non-self-excitable, it is required that the NED (γ3−γ2)/N is maximal and (γ2)/N minimal.
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CEO of Professional Science Editing for Scientists @ prosciediting.com