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Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases.
It will help us to verify tightness of solutions while coefficients are perturbed in a suitably bounded way (see Lemma 31 below).
We propose a novel approach called "Contextual Biological Process Linkage Network" (CBPLN) that focuses on computing which processes in the cell are perturbed in a particular context and how these processes are linked to each other.
Our approach is a complement to a suite of methodologies that integrate physical, signaling, regulatory, and functional networks with measurements of molecular profiles such as transcriptional, proteomic, or metabolic data to compute the response network, which may be defined as the sub-network of interactions that are perturbed in a particular condition.
The L/C patterns of misregulation in cli186 that are perturbed in a L and C interaction are in bold.
Thus, although most regions are perturbed in a generally similar way by the different ligands, there are some differences.
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Starting from the results of [11], in [13], the authors of the present paper prove an analogue of the previous result when the critical Zygmund class (L log L ^{frac{1}{2}}(Omega)) is perturbed in a weaker way, namely with perturbations of order (log log log L).
Furthermore, if m nodes out of n nodes can be perturbed in a network, we can use the information of the corresponding m perturbation experiments to (i) infer the complete sub-network containing only the m perturbed nodes and (ii) to infer edges leading from the m perturbed nodes to the n − m unperturbed nodes.
Functional studies demonstrated that these pathways were perturbed in a manner dependent on the SOD1 mutation.
We show that a commonly used finite deformation linear convolution model results in non-physical energy growth and finite-time blow-up when the system is perturbed in a linearly unstable direction and followed nonlinearly in time.
Figure3 shows the diffusion of risk after the system has been perturbed in a single location (representing a burglary event).
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