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However, since myogenic signalling is perpetually active, the canonical mechanism of proteolytic shedding of TNF would rapidly deplete the constitutive TNF resources and is, therefore, intuitively unsustainable.
If we were perpetually active, we would also be perpetually needing food, so the evolutionary strategy would be too inefficient – running around consuming as much as possible so that we can carry on running around.
Of the options available, an mTNF signal makes intuitive sense: since myogenic signalling is perpetually active, proteolytic shedding (that cleaves mTNF to release sTNF) would rapidly deplete cellular TNF and is, therefore, unsustainable.
And dancegoers are perpetually curious.
Boundaries and distributions are perpetually shifting.
Some successful performers are perpetually on, and some are just perpetually pushing.
Only the British are perpetually at war.
America is crawling with banks and they are perpetually consolidating.
Many locals say that they are perpetually in the dark.
Republicans are perpetually trying to do what Ronald Reagan did.
His knees and elbows are perpetually scraped.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com