The gelatinases (MMP-2/gelatinase A and MMP-9/gelatinase B) are overproduced in joints of patients with RA [ 16- 18].
We have shown that pectinolytic enzyme genes are overproduced in the gongylidia of leaf-cutting ant fungal symbionts.
Furthermore, Reactive Oxygene Species (ROS), metabolites that are overproduced in cancer cell as a result of transformation process, induced nuclear export of proHB-EGF in TCCSUP cells.
Numerous cytokines are overproduced in the inflamed joint, and macrophages and synovial fibroblasts are an important source of proinflammatory cytokines.
Because ACs are overproduced in this context (Kay et al., 2001), the thickness of the IPL in zebrafish may largely reflect the contribution of AC processes.
Th1 cytokines that are overproduced in psoriasis are thought to promote insulin resistance as well.
Reactive oxygen species (ROS), which likely contribute to the pathophysiology of endothelial dysfunction, were shown to be overproduced in the aorta of rats with AIA [ 35].
The ErbB2 receptor is overproduced in approximately one-third of breast tumors, and it correlates with poor clinical prognosis [ 1, 2].
It is overproduced in adipose and muscle tissues of obese humans and in rodent models of obesity.
The mouse model of MS in which glucocorticoid is overproduced in some tissues is not mutually exclusive of the findings demonstrated in our study.
