However, starting in December 1986, premenopausal patients were only randomised to treatment arms A and C. Chemotherapy was administered according to the modified Bonadonna CMF regimen, which consisted of 500 mg m−2 cyclophosphamide, 40 mg m−2 methotrexate, and 600 mg m−2 fluorouracil administered intravenously on days 1 and 8 of a 4-week treatment period.
To the best of our knowledge, there are only two randomised control trials that have made this head to head comparison.
There are only few randomised controlled trials of interventions using practice facilitation as an implementation strategy to enhance the implementation of the chronic disease management [ 37, 38].
To the best of our knowledge, there are only three randomised controlled trials examining the efficacy of SDM for schizophrenia treatment.
There are only four published randomised trials of chemotherapy for NETs, and none have compared chemotherapy with best supportive care.
There are only two published randomised controlled trials comparing expectant management and definitive treatment of prostate cancer.
However, the usual methods for assessing bias using visual or statistical tests are only applicable to randomised controlled trials or trials with matched controls [ 236, 237] and not to observational studies.
Although research on post-cancer fatigue has increased in the last decennia, there are only a few randomised-controlled trials (RCTs) investigating the management of post-cancer fatigue.
However, there are only a few, small randomised trials of neoadjuvant trastuzumab, and so far no study has shown that neoadjuvant trastuzumab can improve overall survival (Rowan, 2009).
There are only a small number of randomised controlled studies on stretching and exercise.
The authors are only aware of three previous randomised controlled trials which have evaluated pre-registration IPE interventions [ 36, 39, 40].
