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We have shown that btg and rblA are on the same pathway controlling preference for ALC fate.
Additional adjustment for BMI to explore residual confounding showed weaker nonsignificant associations, but it is questionable whether inclusion of BMI represents overadjustment because BMI and sex hormone levels are on the same pathway.
Historically, over-representation analysis (ORA) was the first method applied, which statistically evaluates the fraction of genes (e.g. all significantly over-expressed genes in a certain disease entity) in a particular biochemical pathway and compares it to a background distribution (e.g. all screened genes in the study that are on the same pathway).
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Therefore, it is clear that these two forms of oxidative stress cannot be used interchangeably nor their effects interpreted as being on the same pathway in studies of aging or oxidative damage.
Nevertheless, our observation that three residues (Tyr 3, Thr 47 and Cys 54) are in a chemical environment that differs from that in the visible state both in the "thermal" and in the CEST-detected exchange partner raises the possibility that these states are not completely independent and may even be on the same pathway.
Moreover, when EGFR was knocked down, the expression of XIAP was dramatically affected, implying that two molecules are on the same signaling pathway.
These data suggest that HMG-CoA reductase and Ubiad1 are on the same metabolic pathway to produce CoQ10 as a potent antioxidant molecule which protects cardiovascular tissues during development.
This explanation does not diminish the importance of trauma as the likely cause of the initial insult that results in a DFU or LEA, but it may be that CKD, neuropathy, PAD, and many other complications of diabetes are on the same causal pathway related to the progressive inability to repair.
"The patient had a mutation in one gene that was right on the same pathway as the therapy," Dr. Baselga said.
We're still on the same pathway as we began.
We suspect a complex relationship between the exposures studied here, some of which may be on the same causal pathway for early death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com