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Matricellular protein knockout mice are often viable, but typically exhibit abnormal responses to mechanical stress, wound healing, inflammation and tumor metastasis.
Mutants affecting these genes are often viable, but show growth and developmental defects, suggesting incomplete functional redundancy within the families.
Mutants of C. elegans with widespread nervous system defects are often viable, which means that mutations in a large number of neuronal genes can be tested for altered behaviors in genetic screens.
Knockout mouse models of these specific matricellular proteins are often viable but characteristically display impaired responses to mechanical stress and wound healing (Bradshaw et al, 2003; Rios et al, 2005; Vetrone et al, 2009; Okamura et al, 2010).
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First, the wider issue of case finding and early recruitment was a major challenge, especially early detection of women with new fistulae for whom conservative treatment is often viable [ 25- 27].
In their 1919 book, Inbreeding and Outbreeding, East and Jones laid the basis for the concept of heterosis, or hybrid vigour (that hybrids are often more viable, stronger, and more fertile than inbred strains).
Experimental methods for 3D structure determination, mainly Nuclear Magnetic Resonance (NMR) spectroscopy and X-ray crystallography, are often not viable for studying oligosaccharide conformations in high detail.
Even the alternatives available under the three-month provision for those who cannot find work are often not viable.
Owing to the inherent properties of MM, surgical resection or radiotherapeutic intervention are often not viable treatment options (Palumbo et al, 2008).
Early leadership behaviors are often no longer viable.
But there are often no other viable options.
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