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The phrase "are often unknown" is correct and usable in written English.
It can be used when discussing things that are frequently not known or not understood in a particular context.
Example: "The causes of certain diseases are often unknown, making treatment challenging for medical professionals."
Alternatives: "are frequently unclear" or "are commonly undiscovered".
Exact(60)
Enemies are often unknown.
The messages often come from faked e-mail accounts; the intended recipients are often unknown.
These efforts are often unknown by the mass public and as a result are undervalued in the economic marketplace.
Their challengers are often unknown, and making it harder for them to raise money increases the odds they will stay that way.
In a society where headlines of violence are almost commonplace, the families of the perpetrators are often unknown and largely unheard from.
Because the genetic and environmental factors that underlie multifactorial disorders are often unknown, the risks of recurrence are usually arrived at empirically.
For one thing, they hand partial control over charity brand names and trademarks to users who are often unknown to the nonprofit groups they support.
But there's also still room and time to wind your way through histories and aesthetic traditions in which the makers are often unknown or forgotten.
The causes of death are often unknown.
Units and unitTypes are often unknown or very difficult.
However, these parameters are often unknown and not easy to determine.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com