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The signal transduction pathways that control thymocytes are often recapitulated in mature T cells.
Just as normal developmental mechanisms are often recapitulated in certain disease states (Reya et al, 2001), the corresponding developmental defects might provide unique insights into possible treatments for those diseases.
Developmental pathways are often recapitulated during lung repair and their chronic and sustained activation may lead to lung remodeling observed in chronic diseases such as IPF, COPD and chronic asthma.
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Complicated models are often built to recapitulate complex dynamic data.
Although cellular and animal models confirm a role for aggregation in ALS, results are often contradictory and models fully recapitulating ALS pathogenesis are mostly lacking.
In an effort to improve these properties tissues grown in vitro are often subjected to mechanical stimuli that aim to recapitulate the in vivo physiology.
While small animal models such as rodents and rabbits are often used in early pre-clinical work, larger animals that better recapitulate the anatomy and loading of the human joint are required for late-stage preclinical evaluation.
Although EC functional assays can recapitulate one or more aspects of angiogenesis in vitro, they are often limited by undefined substrates and lack of dependence on key angiogenic signaling axes.
However, the results of a number of studies comparing the response of cells to drugs are often different when cells are cultured in 2D due to the failure to recapitulate the native 3D in vivo state [ 27, 30].
However, human HNSCC, are often deficient in PTEN, and show infiltration of inflammatory monocytes, angiogenesis and NF- κB activation, which were recapitulated in mice deficient in Pten and Tgfbr1.
CA75 cells recapitulate the genetic and biochemical features of mtDNA diseases in patients, where mutations are often heteroplasmic and result in partial OXPHOS defects.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com