Sentence examples for are often defective from inspiring English sources

These functions are often defective in patients with inflammatory conditions such as MetS and T2D and can add to a patient's overall CV risk.

As a Ser/Thr phosphatase, PP2A counteracts the actions of Ser/Thr kinases, which are often defective or deregulated in cancer.

Cancer cells are often defective in one of six major DNA repair pathways, namely, mismatch repair (MMR), BER, nucleotide excision repair (NER), HR, NHEJ, and translesion synthesis (TLS) [ 216].

You could overclock the hell out of those things because they were often defective 400- or 500-megahertz processors.

The endogenous (body's own) insulin is assumed to be constant since the normally glucose-dependent insulin production is often defective in critically ill patients.

With an important role in maintaining anoikis, Smad4 is often defective in cancer by means of mutation or deletion [ 82].

The tumor harboring p53 mutation is often defective in transcription activity [ 53]; mice expressing defective p53 transcription activity are predisposed to tumors [ 4].

Models also demonstrate that bone repair is evident when inflammation wanes, but cartilage repair is more difficult to achieve and is often defective.

However, compliance with long-term dosing is often defective, either by negligence or caused by vomiting and other gastrointestinal adverse drug reactions [ 2].

Furthermore, and because the assembly of such mechanosensitive actomyosin bundles is often defective in cancer cells, it will also be important to study this pathway's significance in the context of cancer progression.

By causing an increase in acetylated histones and other proteins, HDAC inhibitors may disrupt the cell cycle and induce apoptosis of tumour cells by targeting cell cycle checkpoint controls – a G2 check point, which is often defective in tumour cells, and a mitotic spindle check point (Warrener et al, 2003).