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The phrase "are of substantial" is correct and usable in written English.
It can be used when discussing the significance or importance of something in a formal context.
Example: "The findings of the study are of substantial importance to the field of medicine."
Alternatives: "are of considerable" or "are of significant".
Dictionary
are of substantial
verb
Representing or , chiefly in depictions of colloquial speech.
Exact(52)
These systems are of substantial industrial interest and are substantially larger than those in Rodrı́guez-Toral et al., Computers and Chemical Engineering, August 2000.
Most are of substantial size, long-legged and long-necked, and adapted for wading.
Zola went on to produce these 20 novels most of which are of substantial length at the rate of nearly one per year, completing the series in 1893.
The Lamé's constants are of substantial interest for plastic materials.
Rational approaches to modifying cells to make molecules of interest are of substantial economic and scientific interest.
Sheet and film processes, which include papermaking, polymer film extrusion, and adhesive coating, are of substantial industrial importance.
Similar(7)
Or I could sell it; it may be of substantial value.
He is insistent, though, that the fixture will be of substantial value for a number of reasons.
Information was shared freely, and was of substantial help to us in our investigations in the U.S.
That is because the gene chips are complex, raising new technological issues, and also because the test could be "of substantial importance in preventing impairment of human health".
Even some of Mr. Bush's Capitol Hill allies are skeptical of the assertion that the tax cut would be of substantial help in reviving the economy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com