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The finding that antibody levels to VAR2CSA are dependent on sex and gravidity and are associated with reduced consequences of PAM [15], [16] has further strengthened the candidacy of VAR2CSA as the CSA adhesin in PAM.
Antibodies against VAR2CSA are sex-specific and parity-dependent, and high levels of such antibodies are associated with reduced consequences of PAM, making VAR2CSA a promising target for vaccine development [6], [7].
The gains in SUVmax were most pronounced with UHD, which is likely to be a consequence of reduced post-filtering compared with HD when voxel COV was matched (2.9 mm for UHD and 3.8 mm for HD).
The effects in longevity observed in AT1A-deficient mice are likely the consequence of reduced mitochondrial damage due to attenuation of oxidative stress and the increased expression of Nampt and Sirt3 survival genes (Fig 3).
Pressure ulcers are a consequence of reduced mobility which may result from a wide range of both acute or chronic illness and treatment.
Thus, genes found to be differentially regulated in response to both treatments is presumed to be a consequence of reduced SnRK1.2 activity.
Whether this pulmonary haemodynamic effect could be a consequence of reduced angiotensin II levels is unknown because ACE inhibition increases bradykinin levels [ 22], which may dilate pulmonary vessels [ 23].
The use of a visual-tracking paradigm for attention assessment is based on the hypothesis that attention impairments in concussion patients are a consequence of reduced efficacy of predictive timing (Ghajar & Ivry, 2008).
However, attenuated maturation and decreased effector functions in these mice are essentially downstream consequences of reduced number of antigen-specific CD8+ T cells.
Thus, the short telomeres in tlc1 Δ48 and yku80 -135i cells could be a consequence of reduced amounts of holoenzyme being imported and/or retained in the nucleus.
The reduction in Aβ1 42 accumulation we observe following genetic down-regulation of autophagy activity is thus likely to be a consequence of reduced convergence of autophagy and endosomal vesicles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com