Macrophages are involved in remodeling/repair, neovascularization, atherosclerosis, and tumor development and are now considered multifunctional cells, more so than immune cells [ 1].
In the last decades the paradigm of including excipients in the formulations as inert substances, aiding production processes, has changed and they are now approached as multifunctional compounds.
In addition to their traditional functions of lending books and providing spaces for reading newspapers and magazines, libraries are now becoming more multifunctional, providing space for different activities, including work.
Nucleoli are now recognized as multifunctional domains containing some 700 different types of proteins involved in several fundamental processes of cell life such as ribosome biogenesis, RNA maturation, cell cycle and apoptosis regulation [1] [3].
Circulating monocytes are now recognized as multifunctional precursors, playing critical roles not only in immune and inflammatory responses but also in tissue regeneration and in pathologic tissue remodeling, such as excessive fibrosis and tumor development [ 13, 14].
AARSs, such as glutamyl-prolyl-tRNA synthetase, glutaminyl-tRNA synthetase, and lysyl-tRNA synthetase, are now known to be multifunctional, participating in a variety of functions including transcription, translation, splicing, inflammation, thrombopoiesis, and apoptosis [ 3].
Reviewer 2 By concentrating on catalytic function in their discussions of evolutionary pressure, the authors may be missing the fact that an increasing number of enzymes are now recognized to be multifunctional (sometimes also called "moonlighting") proteins, with alternative, distinct, functions that may also be species-specific.
Adipocytes are now recognized to form a multifunctional organ not only for lipid storage but also for secreting numerous adipokines and cytokines that play roles in inflammation and insulin sensitivity [1].
In addition, multifunctional protein nanoparticles capable of carrying both therapeutic and diagnostic agents are now being explored for more effective cancer management.
The reasoning – and it's convincing – is that e-book content is now available on most multifunctional devices like mobiles and tablets that work well enough as book readers, while having other functions.
