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However, these results are not validated by a re-sampling technique as bootstrapping or cross-validation and are based only on a single marker.
Patching can create new problems whenever the patches are not validated carefully.
The vast majority of musculoskeletal models are not validated against primary experimental data.
The European Organization for Research and Treatment of Cancer EORTCC) risk scores are not validated in an independent patient population.
These ad hoc models often utilise simple linear relationships, and are not validated against real data or more detailed models.
Models formulated to associate odors and odorants in many industrial and agricultural fields ignore the potential effect of relative humidity on odor perception, and are not validated.
The Searle studies predated GLP standards but their methodology was comparable; transgenic mouse models are not validated, but are accepted as supporting data.
However, many of the outcome measures used in prognostic and antibiotic studies are not validated and do not capture features of outcome that are important to patients.
In this (screening) experimental phase the models are not validated for prediction.
In some of these previous studies, the proposed analytical models are not validated.
The category of models having a sound underpinning on theoretical understanding are not validated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com