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The other option is to set a threshold that will filter off hits that are not under functional constraints.
This difference arises due to the inherent bias in bacterial genomes toward deletions, such that sequences that are not under functional constraints are removed (Mira et al. 2001).
Our approach, while seeking to identify regions of the genome that are not under functional constraint instead, have adopted such underlying logic and applied it to species whose genomic sequences are not yet available.
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Although we found multiple lines of evidence suggesting that E. coli genes lacking orthologs or functional annotation are not under selection for reduced mRNA secondary-structure stability, the generality of this finding was unclear.
Interestingly, for both cell cycle related TFs (e.g. MCM1, FKH2, NDD1 and ACE2) and TFs that are not functional under growth conditions (e.g. YAP1 and SUM1), the discriminative power of histone modifications in Figure 2 is much stronger than that in Figure 1.
Portions of the main screen are apparently under construction and are not currently functional.
Under "Air Travel During Pregnancy," there is this: "Women traveling with infants should keep in mind that newborns under 6 weeks old should not fly because their alveoli are not completely functional".
"These cars are not functional," he said.
NSIS installers are not functional.
These people are not functional stoners.
Oblique context are not truth-functional.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com