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WHO points out that one cluster did not have two of the cases lab confirmed and further points out, as a matter of baseline information, that some viruses are able to cause limited human-to-human transmission under conditions of close contact but are not transmissible enough to cause large community outbreaks.
Because noninfectious causal agents are not organisms capable of reproducing within a host, they are not transmissible.
There are also less common causes such as plant viruses, which are not transmissible to humans, or mineral deficiencies in the soil, which can be bad news for plants but don't really have an effect on us.
Several genetic prion diseases, in fact, develop in the absence of protease-resistant PrP or in the presence of other abnormal forms of the protein, and are not transmissible to laboratory animals [9] [13].
Transmission of buffalo-derived T. parva to cattle results in a rapidly lethal disease, but in many cases the parasites do not differentiate to the erythrocyte-infective stage and are not transmissible by ticks [6], [7].
Both of these strains are virulent, and are not transmissible by D. andersoni ticks.
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Although AS was reported in 2005 to be transmissible into mice transgenic for ovine PrP [ 33]and into sheep [ 34] in 2007, the epidemiological evidences cited above suggest either that AS is not transmissible by direct contact between sheep, or that the transmission rate under natural conditions is low.
On the other hand it is known that interspecies transmission can fail e.g. Syrian hamster Scrapie is not transmissible to mice [8].
But, crucially, scrapie is not transmissible to cows, or to humans, it is species-specific.
Investigations to date reveal that the syndrome is not transmissible person to person.
Studies published recently in Science and Nature by two research groups suggested that one reason A(H5N1) is not transmissible among people is that the virus can latch on only to cells deep in the respiratory tract, too far down to be coughed up or sneezed out to infect other people.
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