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However, these observations are not recapitulated on application of transmural pressure (PTM) oscillations (that mimic tidal breathing and DIs) in isolated intact airways.
Although the diffusion-limiting properties of cartilage are not recapitulated in cultured chondrocytes, the absence of active rhGALNS and subsequent accumulation of KS, as well as expression of chondrogenic genes, make MPS IVA chondrocytes a valuable new model of human MPS IVA in vitro.
These sequences drive identical expression patterns that are not recapitulated in cross-species assays.
However, some important pathologies such as hepatomegaly, renal cysts, and bone abnormalities are not recapitulated.
One limitation of iPSC-based approaches is that AMD might involve systemic defects that are not recapitulated in the culture of a single cell type.
Although both measurements are rough, we can surmise that if there are selected traits that are not recapitulated by, their associated advantage cannot be very large.
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However, cell lines are clonally homogenous and are not recapitulating the complex tumor microenvironment in vivo.
The allogeneic extracellular matrix derived hydrogels elicited significantly reduced total, human specific, and CD4+ T-helper cell infiltration in humanized mice compared to xenogeneic extracellular matrix hydrogels, which was not recapitulated in wild type mice.
The ropB mutation of strain 5628 was not recapitulated on passage in the mouse subcutaneous infection model.
In addition to the usual caveats of overexpression data, this result was not recapitulated by the same group when using a different plasmid system [22].
However, this seems unlikely because such an effect is not recapitulated in our growth curves (Fig. 8C and 8D, Figure S5).
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