For a dry powder formulation platform to be suitable for pulmonary delivery of potent biopharmaceuticals, e.g., proteins and peptides, it has to be not only efficiently and reproducibly aerosolisable, but also capable of creating a matrix suitable for stabilising the relevant biomacromolecules at temperatures appropriate for storage and distribution.
Transient exposure of human sarcoma cell line, containing Cre-dependent lacZ reporter, resulted in efficient recombination in the host chromosome, indicating that the bacterially delivered protein was not only efficiently localized to the nucleus but also retained its biological function.
We found that FLAG-tagged VHL-SUMO1ΔC4 is not only efficiently associated with native HA-VHL, but also induced SUMOylation and dimerization of the HA-VHL isoform which is similar in size to the mono SuVHL and oligomerized SuVHL-L protein, respectively (Figure 3G, lane 1).
She said that her involvement in a trade union "gives me the experience and insights on capital projects to make sure that schools are not only built, but built efficiently".
If not they would be fools, because they could achieve exactly the same outcome — seasoning their food with fresh ketchup — by buying one of Heinz's plastic bottles, which are not only cheaper, but do the job more efficiently.
The proposed model is not only able to efficiently simulate stereoscopic visual attention of human eyes, but also can reduce noise in each stimulus channel.
Furthermore, our electrophysiological studies show that it is not only transported more efficiently by hCNT1, but it is also selectively transported by hCNT1.
Interestingly, they found that in the absence of endogenous RPS51, RPS51-lacZ was associated with polysomes, but in the presence of endogenous RPS51, RPS51-lacZ was not only expressed ten times less efficiently but also predominately located in the nucleus and not in polysomes.
This strategy is entirely mesh-less and is not only helpful to restore the image efficiently and resolve the edges due to is discontinuous jumps but also to eliminate the staircase effect and preserve the textures during the restoration process.
The key, Ibanez said, is not only working hard, but also smart and efficiently, and staying motivated.
