Moreover, it was not able to trigger acute oral systemic toxicity in mice, being classified as a compound with low acute toxicity hazard (2.000 mg/kg > LD50 < 5.000 mg/kg).
The competing situation between heparin and AT for endothelial GAGs is of crucial relevance, as AT is not able to trigger the release of PGI2 from the endothelium after the GAGs have been irreversibly blocked by heparin (Fig. 5 ).
In contrast, the flagellin-deficient strain WTM−F− was not able to trigger the release of LDH or secretion of mature IL-1, respectively.
Eliminating low frequency signals means constant stimuli, whose frequency can be considered as 0, is not able to trigger the pathway.
The knock-down of Bcl-Xl in hMSCs made these cells susceptible to low concentrations of etoposide (i.e. 50 µg/ml) that was not able to trigger apoptosis in hMSCs infected with a scr-shRNA (Figure 5B).
Previously, we have ruled out the possibility that DCs and macrophages in the BMOG mice present the MOG peptide, as we found that they were not able to trigger 2D2 TCR expressing cells in vitro [19].
Interestingly only one (SF162) out of 6 R5 viruses was not able to trigger migration but was transcytosed through epithelial cells.
In contrast to TNF-α and RANKL, IL-1β is not able to trigger osteoclastogenesis but can activate preformed osteoclasts [ 16].
The phosphorylated form of eIF-2 is not able to trigger initiation resulting in the inhibition of protein synthesis [ 26- 28].
