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However, most of the occurring fusion genes are non-functional (loss of function of one or both genes).
First, it is possible that although the tumours possess ER, the receptors are non-functional and not functionally connected to downstream signalling.
This dramatic architecture variation might imply that the isoforms are non-functional or that they perform a completely different function.
It is therefore questionable whether these are non-functional pseudogenes, newly evolved genes or DNA elements with specific functions.
Kv7.2 channels that carry a mutation in helix A or helix B, each of which disrupts CaM binding individually, are non-functional.
The researchers provide evidence that some BRCA1 VUS are non-functional — a subset that should be monitored carefully in the future.
Many traffic lights across the island are non-functional and in my neighborhood many streetlights still do not work, leaving many streets dark at night.
Since lactides are non-functional, they are copolymerized with hydrophilic monomers or conjugated to a hydrophilic moiety to form hydrogels.
These typically replicate the external features to allow for the design and testing of peripherals such as cases and holders and are non-functional.
The management interfaces are non-functional server interfaces (ConfigInM, ConfigOutM, and ActivateQoS in green in Fig. 1).
Either apes don't have the forebrain pathways involved in vocal learning, he says, or the pathways are non-functional for some reason.
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