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Sequences of full mt genomes are necessary to decipher yet not defined haplotypes and assign them to their phylogeographic environment.
Akin to SphK1, in vivo active small molecule SphK2 selective inhibitors are necessary to decipher its role in physiology and disease states where S1P signaling might be awry.
High-throughput analyses (e.g., Microarrays) combined with statistical and bioinformatics data analyses are necessary to decipher such complex biological process [ 8, 9].
Still, the phenomenon of mitochondrial exocytosis might be a cleaning mechanism of defect mitochondria; however, further studies are necessary to decipher the relevance of these observations.
Regarding that functional elements like macromolecular complexes interact at Golgi apparatus in distances far below light microscopic resolution, and that vesicles or cisternae of different compositions are homogenized during biochemical isolation or fractionation, it is obvious that high-resolution imaging technologies like cryo-electron microscopy are necessary to decipher Golgi functionality.
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Human intervention and interpretation is necessary to decipher nuances in data for effective reuse.
In addition, further research is necessary to decipher the effect of cardiac sympathetic innervation inhomogeneity on susceptibility to AF in patients suffering from AF paroxysms and on AF relapses in patients following PVI.
Simulations of antimicrobial peptides in membrane mimics can provide the high resolution, atomistic picture that is necessary to decipher which sequence and structure components are responsible for activity and toxicity.
Therefore, in such a conflicting and ambiguous nature of NMs in plants, it is necessary to decipher the mechanism of cellular, biochemical and molecular protection render by NMs under stressful environmental conditions.
Such a precise study on 5-HT and DA levels at the neural circuit level would be necessary to decipher the neurochemical basis of abnormal behaviors in patDp/+ mice.
Additional experiments will be necessary to decipher this issue.
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