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In addition, the number and functions of Tregs cells are necessary in controlling autoimmunity since depletion of CD4+CD25+ T cells in mice, mutations in the Foxp3 gene, or environmental agents affecting Treg cells cause or predispose to autoimmunity [ 116] because the lack in balancing the activity of self-reactive T cells produced in the thymus.
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Mutation discovery was necessary in controls as well as cases, in order to distinguish a substantial risk attributable to rare alleles collectively from a high frequency of neutral mutations.
Spike in controls are necessary in this case.
However, others argue that true placebo controlled trials are necessary in situations where no effective therapies have been established and mechanisms may be non-specific [ 41, 42].
3, 5 Rigorous case investigation and reactive case detection activities that do not generally occur in control settings are necessary in elimination settings to track secondary cases that arise in these foci.
Based on these calculations, and taking into account a loss-to-follow-up of 20%, it was estimated that 60 construction workers are necessary in both the intervention and control group.
Such control systems are necessary in the case of robot companions, where the owner of the robot may demand from it to provide many services.
EU leaders said measures to restore confidence in the bloc's banks "are urgently needed and are necessary in the context of strengthening prudential control of the EU banking sector".
Tumours overexpressing cyclin D1 were further associated with a slightly improved survival, and in summary we show that randomised treatment trials including an untreated control arm are necessary in order to differ predictive and prognostic information.
Surgical management may be necessary in poorly controlled or recurrent UC.
However, 4.1B has been shown to be necessary in juxtaparanodes only, controlling the distribution of Caspr2 and thus the expression of Kv1 channels [ 29].
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