However, having such information is necessary for validation of computational models.
Further testing in a larger study is necessary for validation of these results.
Evaluation with large samples will be necessary for validation in serum platforms such as the ELISA assay.
A larger study with subjects representing various age groups 20-300, 30-40…80-90 y. o). is necessary for validation of these initial findings.
Further well-designed human studies are necessary for proper validation.
Moreover, such measurements are necessary for the validation of flow simulations of three-phase flows.
However, further feasibility tests on LRVs are necessary for the validation of the indirect method, since the actual running environments are more complicated than those considered in the simulations.
Quantitative data on very distal (> 1000 km) tephra deposition during modern eruptions are few, but they are necessary for the validation of dispersion models (Witham et al. 2007) and to understand the formation of cryptotephra layers, which are an important dating tool (Lawson et al. 2012).
Further multi-organ based histopathological studies in multiple organs are necessary for such validation.
IgM memory B cells are a potential parameter for assessing splenic function; however, more studies are necessary for its validation.
