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This finding also highlights the fact that coagonists are necessary for functional modulation in addition to channel activation of NMDARs.
While this is a relevant constraint for cellular structures such as the nuclear pore complex [ 43], protein complexes involved in signaling or even in forming the cytoskeleton have transient associations that are necessary for functional signaling [ 44- 46].
This indicates that multiple levels of regulation are involved in mammary-specific gene expression, and that in addition to individual ligand requirements cooperative interactions between various ECM molecules and cells are necessary for functional differentiation in culture.
Although cell biological and biochemical analyses have allowed us to derive a mechanistic understanding of these processes in model organisms, that is, yeast and humans, comparative genomic analysis has provided the ability to discern between those features that are the result of lineage-specific modification, and those that are necessary for functional transport in diverse eukaryotic organisms.
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Thus, AGO enrichment analysis is necessary for functional studies on the plant sRNAs.
Existing evidence suggests that arrestins are no exception to this rule: their flexibility is necessary for functional versatility.
However, it is still not known what percentage of dystrophin-positive fibers and what level of expression is necessary for functional improvement.
Joint attention seems to be necessary for functional speech, and deficits in joint attention seem to distinguish infants with ASD: for example, they may look at a pointing hand instead of the pointed-at object, and they consistently fail to point at objects in order to comment on or share an experience.
These investigations provide indirect evidence that viral elimination is necessary for functional improvement in DCMi.
During T cell stimulation, expression of CD44 variants (v3, v6, v9) may be necessary for functional changes post-stimulation [43], [44].
Therefore, immune system modulation is necessary for functional stabilization of the transplantation.
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