The precise mechanism(s) whereby phospholipids enhance FHV RNA replication complex activity is unknown, and there are multiple steps during process of viral RNA replication that could be influenced by these cellular components (see Fig. 1C).
Although the molecular mechanism that leads to distal stop codons leading to slower rates of decapping is not known, it does demonstrate that there are multiple steps in the targeting of an mRNA for NMD.
There are multiple steps in the cellular uptake of lipids.
There are multiple steps involved in the processing of microRNAs.
The occurrence and development of GC is multiple step and multiple factorial processes.
There are multiple, interrelated steps where a plethora of different parties are involved, including researchers, clinicians, healthcare providers, funding and regulatory agencies, legislative, educative, and health insurance bodies, industry and patient groups.
X-linked lncRNAs are known to be involved in multiple steps of control of the binary transcriptional state of the X-chromosomes in mammalian females, including initiation, establishment and maintenance of X-chromosome silencing [ 57, 58].
Another line of development are multiple time stepping algorithms that integrate different parts of structures with different step sizes.
XDpr1a and Frodo are the result of a recent gene duplication in Xenopus and intriguingly, studies have shown that XDpr1a and Frodo are involved in multiple steps of the Wnt pathway in either inhibitory or activating roles [21], [22].
