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The phrase "are mostly responsible for" is correct and usable in written English.
It can be used to indicate that a particular group or factor has a significant but not exclusive role in causing or influencing something.
Example: "The researchers found that environmental factors are mostly responsible for the decline in bee populations."
Alternatives: "play a major role in" or "are primarily accountable for".
Exact(55)
Heterogeneous patient populations, limitations of out-come measures and the lack of a uniform control group are mostly responsible for the suboptimal responses.
We are mostly responsible for what is happening here.
About 70% of women say they are mostly responsible for cooking, food shopping and household cleaning.
Italians have long adored it, and are mostly responsible for cultivating it in the United States.
He fully acknowledges that he and other bankers are mostly responsible for the country's housing mess.
There are a number of paramilitary units, which are mostly responsible for internal security.
Mr. Giordano has maintained that overly generous union contracts are mostly responsible for the city's economic troubles.
Similar(4)
Mobile phones and tablets were mostly responsible for the surge in digital news consumption.
He has said the lack of new refineries in the past 25 years was mostly responsible for tight supplies.
Mr. Egan contributed some exterior details, but he was mostly responsible for the inside: dashboard, door handles and other functional parts.
Yet like Burnley they have a lot of self-belief, and they have an outstanding manager who is mostly responsible for that self-belief.
More suggestions(21)
is mostly responsible for
are generally responsible for
are principally responsible for
are largely responsible for
are predominately responsible for
are overwhelmingly responsible for
are usually responsible for
are basically responsible for
are mostly appropriate for
are especially responsible for
are mostly accountable for
are essentially responsible for
are particularly responsible for
are mostly blamed for
are mostly parallel for
are mostly ineffective for
are mostly relevant for
are mostly positive for
are mostly good for
are mostly consistent for
are mostly typical for
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com