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The phrase "are most useful when" is correct and usable in written English.
It can be used to indicate the conditions or situations in which something is particularly beneficial or effective.
Example: "These tools are most useful when applied in real-world scenarios to enhance learning."
Alternatives: "are particularly helpful when" or "are most effective when".
Exact(39)
But realistically, the emotions we have are most useful when we use them to guide our decisions in the future.
Individual cases are most useful when they show us the unexpected and, in research, the unexpected can signal a new truth [ 27].
Others complain that privacy regulations impede effective data access and use for research, as genomic data are most useful when presented in high quality, sufficient samples, and associated with an individual's medical history, etc.
However, power calculations in our opinion, are most useful when there are well-defined end points and using a test with a well-established standard deviation.
Despite the fact that these methods are regularly used, it remains unclear which read-out parameters are most useful when assessing CIA.
Crowdsourcing apps are most useful when you actively take part and share data.
Similar(21)
MRI is most useful when US has detected or suspected anomalies, and more anomalies are detected when MRI and US findings are assessed together.
The graph editor can be used to create the graphs and adjust all the available options, but FORG3D is most useful when automated scripts are used to create the graphs from the experimental data.
When used to differentiate masses, PET is most useful when uptake is at the extremes of metabolic activity.
Geospatial data is most useful when it can be discovered, shared, and used.
Kelly Griffiths, a student studying media production at Bournemouth University, uses the app and says it's been most useful when deadlines begin to loom.
More suggestions(18)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com