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The phrase "are most useful" is correct and usable in written English.
You can use it when describing something that provides significant benefit or utility in a particular context.
Example: "These tools are most useful for improving productivity in the workplace."
Alternatives: "are highly beneficial" or "are extremely helpful."
Dictionary
Exact(58)
This means they are most useful in urban areas.
For this purpose, power formulas are most useful.
For travelers, the City/Regional and Travel categories are most useful.
Observers are most useful where there is a peace to keep.
This is a big loss, because these are the approaches that are most useful in practice.
Crowdsourcing apps are most useful when you actively take part and share data.
We consider photons to be light, because that is clearly what they are most useful for in our world.
They are most useful if you are in or near retirement and you need to hedge a large stock position.
Economic theory suggests they are most useful in particular circumstances: when there is uncertainty about what is the right price.
What is missing amid all this number crunching and modeling is any sense of which methods are most useful when.
Furthermore, dietary strategies are most useful when combined with other approaches, such as smoking cessation and regular exercise.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com