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The phrase "are most profitable to" is correct and usable in written English.
It can be used when discussing the financial benefits or advantages that something provides to a particular entity or group.
Example: "Investing in renewable energy sources are most profitable to companies looking to reduce their carbon footprint."
Alternatives: "are most beneficial to" or "yield the highest returns for".
Exact(1)
The usual critique of solutionism – that it defines social problems too narrowly and usually in terms that are most profitable to those pitching the "solution" – fully applies here.
Similar(59)
The information might also encourage a new source of national revenue through the United Nations program on reducing emissions from deforestation and forest degradation, known as REDD, by highlighting the lands that would be most profitable to protect.
In the steady market, again, it is most profitable to use a fairly high threshold.
We look at a pile of new data and decide what direction is most profitable to follow up," he says.
China's economic success over the past few decades came in part because its central planners outsourced to the likes of Wal-Mart and Carrefour the decisions over what to make that would be most profitable to export.
Check the Grand Exchange watch charts to see which logs are most profitable at what time.
The idea is to give senior consultants an incentive to stay, but to target that incentive to those who are most profitable, rather than simply to those who are most senior.
In general, the effectiveness of offers and which are most profitable vary from person to person.
While flights under two hours are most profitable, as more travelers look to fly farther afield, these airlines want a piece of the action.
Online ads are most profitable.
They've become global networks that design, make, buy, and sell things wherever around the world it's most profitable for them to do so.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com