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The phrase "are most powerful when" is correct and usable in written English.
You can use it to describe the conditions or situations in which something has the greatest impact or effectiveness.
Example: "These strategies are most powerful when applied consistently over time."
Alternatives: "are at their strongest when" or "have the greatest effect when".
Exact(21)
Icon destroyers are most powerful when they hail from within the priestly elite.
The concepts of maneuver warfare, while valuable individually, are most powerful when applied in an integrated fashion.
Quantitative tools in the humanities and the social sciences, as in other fields, are most powerful when they are controlled by an intelligent human.
As the title of the project, "Silent Ballad," suggests, the photos are most powerful when considered together, in the chords formed among images.
But I believe that the sacraments are most powerful when they are extended not simply to the religious and the privileged, but to the poor, the marginalized, the lonely and the left out.
(It is for similar reasons that activists rightly call for an intersectional approach to equality movements, which are most powerful when they address the overlap between different forms of prejudice and inequality, rather than pursuing one cause to the exclusion of all others).
Similar(39)
"We Shall Remain" is most powerful when one senses the emotional power of events still resonating in close descendants of people who experienced the traumas of ethnic cleansing and resettlement, and living survivors of native reeducation policies in the 1950s and '60s.
Recognition is most powerful when it's contingent.
As a medium, online video will be most powerful when it is fluid, like a conversation.
The party, Mr. Cantor noted, "is most powerful when we're all walking in the same direction".
In Section 3.5.1, we asserted that the H3Viewer is most powerful when effectively linked with other interface components.
More suggestions(18)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com