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The phrase "are most helpful" is correct and usable in written English.
You can use it when describing something that provides significant assistance or support.
Example: "The resources provided in this guide are most helpful for new users trying to navigate the software."
Alternatives: "are very helpful" or "are extremely beneficial".
Exact(60)
Weights are most helpful when they help quantify differences in the relative importance of competing (though not necessarily conflicting) values.
If needed, trying different vaping products can help smokers identify which are most helpful in getting them to end smoking.
Finally, parents of stillborn infants can play a critical role in helping clinicians better understand what supportive interventions are most helpful following a stillbirth, as clinicians, too, struggle with how best to support patients during this sad and tragic experience.
They are fully trained public servants and are most helpful.
Facilitation and support are most helpful when fear and anxiety lie at the heart of resistance.
SRs are most helpful if they are current; however, most of them are not being updated.
Have your students try another self-observation about the interventions that are most helpful in falling asleep.
The e-commerce platform Shopify awards bonuses to the employees who are most helpful to customers and other employees.
Specific anecdotes are most helpful, as are direct quotations from tutors and others who know the student.
Those who are afflicted with such conditions deserve whatever safe forms of treatment are most helpful to them, including medication and psychosocial support.
The introduction, chronology and notes are most helpful, but the impression that this volume contains all the poetry and translations of Pound except the "Cantos" is misleading.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com