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The phrase "are more difficult to run" is correct and usable in written English.
It can be used when comparing the difficulty of running different tasks, processes, or activities.
Example: "The new software updates are more difficult to run than the previous versions, causing delays in our workflow."
Alternatives: "are harder to execute" or "are more challenging to operate".
Exact(2)
But the inspection evidence shows that big prisons are more difficult to run than smaller ones and often provide less good outcomes.
Properly conducted randomised controlled trials are more difficult to run with orthopaedic implants than with drugs or other interventions, and this may also have contributed to the paucity of good quality evidence in this sphere.
Similar(58)
"It will be more difficult to run a company here," said Andreas Lauffs, a lawyer at Baker & McKenzie, which represents many of America's biggest corporations in China.
However, the chief inspector of prisons, Nick Hardwick, told The Report that new prisons were "very difficult to run" and, although there were some "advantages of scale", big prisons were more difficult to run than smaller ones, he said.
Privately run sites are more difficult to include.
The effects on teachers and on students' long-run outcomes are more difficult to judge.
Concentrate on lines that run from left to right (horizontally) as these are more difficult to remove.
The institutionalists are more difficult to categorize.
Meteorite fragments are more difficult to explain.
These are more difficult to develop.
Longer passwords are more difficult to crack.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com