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The phrase "are more difficult in" is correct and usable in written English.
It can be used when comparing the difficulty of tasks, subjects, or situations in different contexts or environments.
Example: "Mathematics problems are more difficult in higher education compared to high school."
Alternatives: "are harder in" or "pose greater challenges in".
Exact(9)
On the whole, restrospective cohort studies, particularly studies on patients, are more difficult in Japan than in the United States.
This observation explains why the treatment and asthma symptoms control are more difficult in women than in men.
TB detection and treatment are more difficult in countries, like Pakistan, that are facing complex emergencies, including humanitarian crises and conflicts (2 ).
These approaches are more difficult in complex polyploids such as switchgrass, Miscanthus, and sugarcane, but there has been success in QTL mapping for these species (see examples below).
Subperiosteal exposure of the proximal tibia and eversion of the patellar mechanism are more difficult in the post-osteotomy knee due to soft tissue scaring.
Interpretations of the lack of main effects of age and remoteness and the main effect of social support on the likelihood of high psychological distress are more difficult in the presence of their significant interactions.
Similar(51)
But it was more difficult in Russia".
That's more difficult in the backwash of Mail opprobrium.
But business was more difficult in Germany and other countries.
The situation is more difficult in a situation comedy.
But socialising will be more difficult in his new job.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com