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Evidence also suggests that the expression and function of ExsA are modulated by several upstream regulatory proteins, including the cAMP-dependent transcription factor Vfr [26], the two-component hybrid regulators RtsM and RetS [27], [28].
Because gamma oscillations are expressed differently under different conditions and are modulated by several factors, there is still a poor understanding of their implication in various brain processes.
The APC/C activity and specificity are modulated by several adaptors/co-activators (Cdc20, Cdh1, Ama1, Mfr1, Rap and Cortex) (Table 1 and Figure 1) [ 7, 10].
However, IL-2 production and consumption are modulated by several known feedbacks downstream of IL-2 signaling (Smith, 1988; Long and Adler, 2006; Villarino et al., 2007; Boyman and Sprent, 2012; Yamane and Paul, 2012), which could alter the dynamic range (Nevozhay et al., 2009; Becker et al., 2010) and T cell number-dependency of IL-2 output over time.
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Because Ehd1 is modulated by several regulators, it acts as a mediator of various floral signals.
Stem cell differentiation is modulated by several key molecules, including cytokines, hormones, and engineered peptides.
The response to the neurotransmitter binding can be modulated by several chemical compounds acting at topographically distinct sites, as documented by a large body of literature.
Importantly, the developmental trajectory of brain changes is not uniform and may be modulated by several factors such as onset of disease mechanisms, risk-associated and protective genes, converging comorbidity, and individual brain reserve.
This proteolytic activity of the aggrecanases can be modulated by several means, including altered expression, activation by proteolytic cleavage at a furin-sensitive site, binding to the aggrecan substrate through the C-terminal thrombospondin motif, activation through post-translational processing of a portion of the C-terminus and inhibition of activity by the endogenous inhibitor TIMP-3.
These main effects were modulated by several interactions.
Moreover, we could demonstrate that sustained regulation is modulated by several factors.
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