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When such requirements are missing, the score of each single parameter will be 0 pts.
If more than 50% of the items for a domain are missing, the score for that domain is not calculated, that is, it is considered to be missing.
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When one or two monitoring parameters necessary to calculate the score were missing, the score was still calculated and the missing value was considered normal and these scores were called "imputed scores".
Where primary canines were missing, the score was determined by the midpoint of the alveolar ridge.
If two or more components were missing, the score for that time point was omitted from analysis.
If any one of the five components of a FLACC score was missing, the score was included and data was imputed using the calculation - (FLACC score/4) x 5.
If more than 50% of the items were missing, the score was excluded from the analysis (as recommended in the SF-36 manual).
We used pair-wise case deletion for missing values, and if more than 50% of the items were missing, the score was not computed.
If a week 14 or week 104 score was missing, the score was imputed according to prespecified methodology wherein the 75th percentile score for all patients at that time point was employed.
If a value for either phase was missing, the score from the available phase was imputed as the cumulative score, as there was fairly high correlation between measures (0.54 for confiding support, 0.45 for practical support, and 0.42 for negative aspects of close relationships).
If more than two-thirds of the items in a subscale were missing, the scores were not computed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com