The phrase "are mediated directly" is correct and usable in written English.
It can be used in contexts discussing processes or interactions that occur without intermediaries or through direct means.
Example: "The results of the experiment are mediated directly by the variables we controlled."
Alternatives: "are facilitated directly" or "are handled directly."
Most likely, these effects are mediated directly by Aβ and not the APP holoprotein.
These ATP effects are mediated directly by P2X and P2Y receptors expressed by microglia [47].
Whether the effects are mediated directly on bone or are secondary to kidney damage is still unclear (Kjellström 1992).
It is thought that these in vivo effects are mediated directly on mast cells, although it remains possible that intermediaries and neural reflexes are also involved 32.
45 In this case, however, it is unclear if the antiviral effects are mediated directly or through the stimulation of immune cells, or both.
We were unable to determine whether these transcriptional changes are secondary effects or are mediated directly by Fur in an iron-independent manner.
This change in insulin sensitivity is believed to be mediated directly by growth hormone binding to its receptor.
Taken together, we consider that the tissue lesion could be mediated directly by the cytotoxicity of Emuc and indirectly by the host inflammatory responses triggered by Emuc although it remains undefined to what extents the two effects of Emuc, respectively, contribute to the tissue damage.
This could have been mediated directly via NK-T cell interactions and/or NK-DC crosstalk.
The inhibition is mediated directly; a single inhibitory spike is delivered to all excitatory neurons whenever any excitatory neuron spikes.
This suggests that lipid changes were mediated directly by the discontinuation of ART and not by HIV replication itself.
