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Both abiotic and biotic stresses are mediated by multiple transcriptional factors, such as NAC, WRKY, MYB, bHLH, bZIP, and ERF (Abe et al. 2003; Li et al. 2013; Puranik et al. 2012; Rushton et al. 2010; Singh et al. 2002; Zhang et al. 2012a).
The interactions of Plasmodium falciparum infected erythrocytes parasitized red blood cells (pRBC) with endothelial receptors and erythrocytes are mediated by multiple Duffy-binding like (DBL) and cysteine-rich interdomain region (CIDR) domains harboured in the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
Since biological processes are mediated by multiple genes working in synchrony and genes are co-regulated, pathway analysis is more conclusive regarding biologic changes.
These findings strongly suggest that potent anti-tumoral effects of cinnamon extract are mediated by multiple action mechanisms.
In addition, the rapid responses to hypoxia are mediated by multiple transduction pathways activated also upon GPER stimulation [ 67, 68].
The pathways regulating the transition of mammalian cells from quiescence to proliferation are mediated by multiple miRNAs.
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Tissue morphogenesis is mediated by multiple extracellular matrix components and by multiple active sites on some of these components.
Cell communication within tissues is mediated by multiple paracrine signals including growth factors, which control cell survival and proliferation.
There is growing consensus that human memory is mediated by multiple qualitatively different systems co-evolved to function in a complementary way.
This mathematical work is motivated by the observation that the mean firing rates of neurons are restored after chronic changes in input statistics and that this firing rate regulation is mediated by multiple slow biophysical changes [3, 5].
Recent findings indicate that root photomorphogenesis is mediated by multiple signaling routes, including shoot-to-root transmission of mobile signaling molecules, direct sensing of light by the roots, and light channeling through the plant body.
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