Exact(1)
Considering the importance of s100 genes in the pathogenesis of epidermal disease – particular S100 proteins are markedly over expressed in psoriasis, wound healing, skin cancer, inflammation, cellular stress, and other epidermal pathological states [ 30] – it appears advantageous to study these processes in the zebrafish model system (cf. [ 48]).
Similar(59)
In some natural populations, Ser/Ser homozygotes are markedly underrepresented, while heterozygotes are markedly over-represented (e.g., Crescent Beach and Chezzetcook, Nova Scotia).
It has been reported that BIRC5 was markedly over-expressed in a broad range of human cancers.
S100A7 is markedly over-expressed in the skin lesions of psoriatic patients.
Intriguingly, genes involved in neurogenesis were markedly over-represented among the cerebellar genes, as was observed for the hippocampal genes.
We could show that ON is markedly over-expressed in pancreatic cancer and chronic pancreatitis (CP) (Guweidhi et al, 2005).
As an additional example, the potent angiogenic factor VEGF is markedly over-expressed in various cell types in the skin of SSc patients [ 55, 56].
The Hoxc8 showed only basal mRNA expression in adult pancreatic tissue (<5 copies per μl), but was markedly over-expressed in PDAC and AIP tissues.
Individuals with lower SEP were markedly over-represented for all causes of preventable death (see supplementary material, Table S1 and S2).
Fitting the alleles in this way did not result in markedly different ROC AUCs than when alleles were fitted directly to the current dataset, indicating that our data are unlikely to be markedly over- or under-fitted.
COX-2, which is normally undetectable in healthy tissue, is markedly over-expressed in colorectal, lung [ 76], prostate [ 77], cervical [ 78], ovarian [ 79], breast, gastric, pancreatic [ 80] and certain head and neck squamous cell [ 81] cancers.
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